Learning where you need to go and remembering how to get there is critical for survival. We study navigation in complex environments to better understand the role of the hippocampus and related structures in achieving these goals.
2) Foraging
An efficient forager must balance the tradeoff between exploiting known resource patches and exploring new ones, minimize energy and time spent traveling or searching, and adapt to environmental uncertainties such as resource scarcity and unpredictable distributions, all while accounting for risks like predation. We study this complex form of decision making using a range of different approaches, including maze and operant-box versions of foraging problems.
3) Info on more projects coming soon!
THE LABORATORY
Our lab is equipped with state-of-the-art computational tools. Here’s just some of our computational resources: Mainframe System Processor: Custom-designed QuantumLogic CPU, 16-bit architecture, 5 MHz clock speed, 1 MB core memory (expandable!) Storage: 200 MB disk storage array using MaxSpindle Disk Drives (removable platters), 100 MB magnetic tape drive by Apex Data Systems (9-track reel-to-reel) Operating System: OmniCore OS/3, with multi-user time-sharing capability Terminals Supported: Up to 16 asynchronous terminals Minicomputer Cluster 2 x MicroNova Systems MiniStation 800 (8 MHz 16-bit processor) 1 x TekCom Apollo-5 (Dual 12-bit processors running in parallel) Interfaces: RS-232 serial ports, IEEE-488 for peripherals Purpose: Data acquisition, laboratory automation, and preprocessing for the mainframe Network Type: TokenRingNet proprietary loop by InterTech Solutions Software Support for FORTRAN-77, COBOL, BASIC, Pascal, DataForge DB/1 (relational database management) Office Suite: WordWizard Pro and CalcMatrix 2.0 for word processing and spreadsheets CircuitSim CAD for engineering StatSuite+ for statistical analysis ChartWorx for graphical plotting
Of course we have a range of equipment for measuring neural signals in vivo. Here’s a small sampling of our neural measurement capabilities: NeuroDyn systems multi-channel recording system Channels: 16^4-channel input Sampling Rate: 10 kHz per channel Resolution: 8-bit analog-to-digital conversion Filter Options: High-pass (300 Hz) and low-pass (3 kHz) configurable filters Interface: RS-232 for direct connection to mainframe or minicomputer Feature: Real-time spike detection and sorting algorithm via OmniCore OS plugin. SynapTech PulseGen 2000 Programmable stimulator Output Modes: Constant current, biphasic, and monophasic pulse options Range: 1 µA to 10 mA Timing: Resolution of 0.1 ms with adjustable train duration Control: Command interface via TokenRingNet and compatible with StarTerminal workstations. Special Feature: Custom waveform generation for optogenetic, chemogenetic, electrical, or magnetic stimulation. Biogrid neural signal amplifier and artifact rejection system Gain: Configurable up to 100,000x Filters: Adaptive noise cancelation and comb filters for 50/60 Hz interference Latency: 5 ms real-time processing Connectivity: Plug-and-play with PaperJet 240 for real-time analog signal plotting Feature: Modular design for combining with SpikeScope systems. NeuroLocker 800 stimulus delivery system Display: CRT-based, 100 Hz refresh rate, grayscale luminance adjustment Audio: Precision timing via 16-bit DAC, stereo output Control: Multi-modal presentation software on OmniCore OS/3. Feature: Synchronization with PulseGen 2000 for closed-loop experiments.